Infantile esotropia manifests before a child is 6 months old and includes a constant, large angle of strabismus, no or mild amblyopia, latent. Strabismus is one of the most relevant health problems of the world, and infantile esotropia is perhaps the most visually significant yet the least. The term congenital esotropia is often used interchangeably with infantile esotropia, but few cases are actually noted at birth. Often the exact.

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Ophthalmology and Visual Sciences. Rogers MDWanda L. History of Present Illness: Incantil patient is a 2 month-old girl referred by her pediatrician for evaluation of esotropia. Her parents noted that the patient began crossing her eyes shortly after birth and feel that it is worsening. They also note that the crossing is a little worse when she is tired and alternates between the right eye and the left eye. The patient was born full term by normal spontaneous endotrpoia delivery without complications.

Thus far she is a healthy baby, growing and developing normally. Equally round and briskly reactive. No relative afferent pupillary defect. Normal anterior segment exam OU without evidence endotroipa cataracts or other media opacities. Normal-appearing optic nerves with cup-to-disc ratios of 0.

At 6 months of age, she underwent uncomplicated bilateral medial rectus recessions ebdotropia The term congenital esotropia is endotropua used interchangeably with infantile esotropia, but few cases are actually noted at birth. Often the exact date of the deviation is not precisely established, but the appearance of an esodeviation by 6 months is widely accepted by ophthalmologists as necessary to make the diagnosis.

Some prefer to use the term infantile esotropia to more accurately reflect the typical postnatal onset of misalignment Nelson, Although the exact etiology of infantile esotropia remains unknown, two conflicting theories have been proposed. The first was proposed by Claud Worth in He suggested that this form of esotropia is “a congenital defect of the fusion faculty” Worth, He went on to describe it as an irreversible defect in the brain’s ability to fuse, rendering the goal of restoring binocularity hopeless.

Worth’s “sensory” theory was countered by Chavasse’s “motor” theory. Bernard Chavasse proposed that the neural components of binocular vision are present in congenital esotropia. He reasoned that the primary problem is mechanical and potentially curable if the deviation could be eliminated in infancy. His theory suggests that abnormalities in binocular vision may be the result and not the cause of early strabismus Chavasse, Until the ‘s studies seemed to support Worth’s view of irreversible loss of binocularity, but over the past fifty years studies have reported favorable sensory results in some infants who underwent surgical correction between 6 months and 2 years.

These more recent findings formed the basis for the current practice of early surgery infanril patients with congenital esotropia.

All children with new-onset esotropia require a thorough history, review of systems, and comprehensive examination. The examination must include assessment of vision, ocular motility, strabismus measurements at distance and near and cycloplegic refraction in endotropoa to general ocular examination. Besides having strabismus, the majority of children with congenital esotropia are developmentally normal. Esotropia, however, can be observed in the setting of neurologic or developmental disorders which highlights the importance of a careful and complete history and endotro;ia.


The key to a successful ocular examination is efficient and accurate methods of testing vision, motility, and ocular alignment. One infanyil of visual acuity testing in preverbal or nonverbal children is the CSM method. C refers to centrality and can be assessed by the location of the corneal light reflex as the patient looks at the examiner’s light with the opposite eye occluded. Normally, the light reflex should be located near the center of the cornea.

S refers to the steadiness of fixation on the examiner’s light under monocular conditions. M refers to the ability of the patient to maintain alignment. The ability of an eye to maintain fixation is assessed by occluding the contralateral eye to stimulate fixation on a target and then assessing whether knfantil is maintained under binocular conditions when the contralateral eye is unoccluded. If, as the contralateral infajtil is uncovered, the eye under examination shifts within 3 seconds or before the patient blinks, the examined eye is said to be “unmaintained”.

The inability to maintain fixation is indicative of amblyopia.

– Ophthalmology – The University of Iowa

In young children, it can be more challenging to obtain ocular alignment measurements. Since there is limited cooperation for cover testing, estimates of the deviation can be made using corneal light reflex tests. The Hirschberg method is based on the premise that 1 mm of decentration of the corneal light reflex corresponds to approximately 15 prism diopters of ocular deviation.

The Krimsky method uses reflection of light produced simultaneously on both corneas. The original method involved placing prism in front of the deviating eye until the corneal reflexes were similar.

Infantile esotropia – Wikipedia

The modified-Krimsky method involves holding prisms before the fixating eye or splitting prism between the two eyes. Again, as the corneal reflections become similar, a quantifiable estimate is made. Patients with congenital endohropia often cross-fixate.

Cross-fixation occurs when the patient prefers to fixate with either eye in adduction. A pattern of cross-fixation does not infer spontaneous or equal alternation or the absence of amblyopia. Close attention needs to be paid to the point at which the alternation occurs.

American Association for Pediatric Ophthalmology and Strabismus

If amblyopia is present with cross-fixation the alternation will not take place at midline; the sound eye will maintain fixation into abduction. If a child has equal vision and cross-fixates, they have no need to abduct either eye and the examiner will note alternation at midline. This apparent abduction deficit can erroneously lead one to suspect a congenital sixth nerve iinfantil.

Assessing motility and the child’s ability to abduct the eye can be demonstrated with the “doll’s head” maneuver—also known as vestibular rotation—or by observing motility with one eye occluded ductions.

This case is an example of a good post-operative outcome with early surgical treatment. The patient presented with a large angle esotropia noted within two months of life. No amblyopia was detected preoperatively. Motility was full and there was no globe retraction—effectively ruling out congenital sixth nerve palsy and Duanes retraction syndrome.

A low-normal amount of endoyropia was found on cycloplegic retinoscopy without significant astigmatism or anisometropia, so no glasses were initiated.

Should any significant refractive errors be detected, the full cycloplegic refraction should be prescribed. Inferior oblique muscle overaction and dissociated vertical deviation DVD occur in more than half of patients with congenital esotropia.

Both of these associations are usually not recognized until after 1 year of age. The primary goal of treating infantile esotropia is to reduce the deviation to orthotropia or as close to orthotropia as possible. In addition to improving alignment of the eyes, additional goals are the development of some degree of sensory fusion and preservation of normal sight in each eye.


Alignment within 10 prism diopters of orthotropia often results in the development of a monofixation syndrome. Monofixation syndrome is characterized by peripheral fusion and central suppression. Even though a macular scotoma develops in the non-fixating eye central suppressionbinocular fusion of points in the peripheral retina is retained peripheral fusion. This small angle deviation generally represents a stable, functional surgical outcome, produces a favorable cosmetic appearance and is considered a surgical success even though bifoveal fusion is not achieved.

Various surgical approaches have been described for the management of congenital esotropia. The most common procedure is bilateral medial rectus recession.

Two-muscle surgery spares the remaining two horizontal muscles for subsequent surgery should it be needed. Studies vary widely in estimates of re-operation but a moderate portion of patients will require an additional surgery in their lifetime. Some surgeons will perform initial 3- or 4-muscle surgeries if the primary deviation is greater than 50 prism diopters Scott, It is important for the ophthalmologist to take time to discuss the condition with the parents or caretakers.

It is also important to convey that this is a long-term condition that requires continued monitoring for amblyopia and stability in ocular alignment. It should be mentioned that a moderate number of patients will require additional surgery at some point in their lives to achieve adequate and stable alignment.

Also, latent nystagmus occurs in up to one third of patients with a history of infanfil esotropia Hiles, And as mentioned earlier, inferior oblique muscle overaction and dissociated vertical deviation DVD occur in more than half of patients with congenital ijfantil.

Parents are rightfully concerned over their child’s long term prognosis, and discussion regarding these apprehensions should be addressed. Surv ophthalmol ; 31 6: Its Causes, Pathology, and Treatment. Worth’s squint or the binocular reflexes and the treatment of strabismus. Baillier, Tindall and Cox, ; p. Surgery for large angle congenital esotropia.

Arch ophthalmol ; November 6, ; Available from: Web Privacy Policy Nondiscrimination Statement. Infantile Congenital Esotropia Gina M.

Eye crossing History of Present Illness: No known strabismus or inherited eye disease Ocular Examination: Age 2 months Visual Acuity without correction: CSM central, steady, maintained OS: UM central, steady, questionably unmaintained Fixes, but does not follow well at this age.

Unable to test Motility and Strabismus: Krimsky and Hirschberg methods Ductions full OU About 70 prism diopters of esotropia with distance endootropia About 70 prism diopters of esotropia with near fixation No palpebral fissure narrowing or globe retraction on evaluation of versions.

Normal mood and behavior; no nystagmus or abnormal head position External Exam: Age 4 months Visual Acuity without correction OD: Krimsky and Hirschberg methods Ductions full OU 65 prism diopters of esotropia with distance fixation About 65 prism diopters of esotropia with near fixation Infanitl Refraction: CSM Motility and Strabismus: