Download Citation on ResearchGate | Endotoxins: Pyrogens, LAL testing and depyrogenation, third edition | This source expertly examines the. Request PDF on ResearchGate | On Nov 30, , Gert Fricker and others published Endotoxins – Pyrogens, LAL Testing and Depyrogenation, Kevin L. well illustrated to support important concepts. This book should be a familiar reference for anyone seriously interested in endotoxin research or testing.

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Summary This source expertly examines the discovery, biological structure, control, and continued clarification of endotoxin from a parenteral manufacturing perspective, with in-depth discussion of state-of-the-art technologies involving Limulus amebocyte lysate LAL such as assay development, automation, depyrogenation.

Completely revised and expanded, this Third Edition contains the knowledge necessary to apply endotoxin testing in the increasingly complex pharmaceutical environment, featuring sections detailing the latest information regarding clinical advances, regulation standards, and validation procedures for computerized kinetic tests.

Table of Contents Background. Endotoxin Relevance and Control Overview.

Endotoxins: Pyrogens, LAL Testing and Depyrogenation

Fever and the Host Response. Endotoxin Structure, Function and Activity. Lesser Endotoxins, Superantigens and Adventitious Agents. Risk Assessment in Parenteral Manufacturing.


Endotoxin as a Standard. Depyrogenation Validation, Pyroburden, and Endotoxin Removal. This book should be a familiar reference for anyone seriously interested in endotoxin research or testing.

Request an e-inspection copy. Good Manufacturing Practices for Pharmaceuticals.

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